1 March 2017 Integrative analysis on histopathological image for identifying cellular heterogeneity
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Abstract
This study has brought together image processing, clustering and spatial pattern analysis to quantitatively analyze hematoxylin and eosin-stained (HE) tissue sections. A mixture of tumor and normal cells (intratumoral heterogeneity) as well as complex tissue architectures of most samples complicate the interpretation of their cytological profiles. To address these challenges, we develop a simple but effective methodology for quantitative analysis for HE section. We adopt comparative analyses of spatial point patterns to characterize spatial distribution of different nuclei types and complement cellular characteristics analysis. We demonstrate that tumor and normal cell regions exhibit significant differences of lymphocytes spatial distribution or lymphocyte infiltration pattern.
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Young Hwan Chang, Young Hwan Chang, Guillaume Thibault, Guillaume Thibault, Brett Johnson, Brett Johnson, Adam Margolin, Adam Margolin, Joe W. Gray, Joe W. Gray, } "Integrative analysis on histopathological image for identifying cellular heterogeneity", Proc. SPIE 10140, Medical Imaging 2017: Digital Pathology, 101400T (1 March 2017); doi: 10.1117/12.2250428; https://doi.org/10.1117/12.2250428
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