In order to explore the laser propagation influence of thermal blooming effect of pipe flow and to analysis the influencing factors, scaling law theoretical analysis of the thermal blooming effects in pipe flow are carry out in detail based on the optical path difference caused by thermal blooming effects in pipe flow. Firstly, by solving the energy coupling equation of laser beam propagation, the temperature of the flow is obtained, and then the optical path difference caused by the thermal blooming is deduced. Through the analysis of the influence of pipe size, flow field and laser parameters on the optical path difference, energy scaling parameters Ne=nTαLPR2/(ρεCpπR02) and geometric scaling parameters Nc=νR2/(εL) of thermal blooming for the pipe flow are derived. Secondly, for the direct solution method, the energy coupled equations have analytic solutions only for the straight tube with Gauss beam. Considering the limitation of directly solving the coupled equations, the dimensionless analysis method is adopted, the analysis is also based on the change of optical path difference, same scaling parameters for the pipe flow thermal blooming are derived, which makes energy scaling parameters Ne and geometric scaling parameters Nc have good universality. The research results indicate that when the laser power and the laser beam diameter are changed, thermal blooming effects of the pipeline axial flow caused by optical path difference will not change, as long as you keep energy scaling parameters constant. When diameter or length of the pipe changes, just keep the geometric scaling parameters constant, the pipeline axial flow gas thermal blooming effects caused by optical path difference distribution will not change. That is to say, when the pipe size and laser parameters change, if keeping two scaling parameters with constant, the pipeline axial flow thermal blooming effects caused by the optical path difference will not change. Therefore, the energy scaling parameters and the geometric scaling parameters can really describe the gas thermal blooming effect in the axial pipe flow. These conclusions can give a good reference for the construction of the thermal blooming test system of laser system. Contrasted with the thermal blooming scaling parameters of the Bradley-Hermann distortion number ND and Fresnel number NF, which were derived based on the change of far field beam intensity distortion, the scaling parameters of pipe flow thermal blooming deduced from the optical path deference variation are very suitable for the optical system with short laser propagation distance, large Fresnel number and obviously changed optical path deference.