8 December 2016 Spectroscopic properties of second generation photosensitizers for photo-diagnostics and photo-dynamic therapy
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Proceedings Volume 10159, Laser Technology 2016: Progress and Applications of Lasers; 101590B (2016) https://doi.org/10.1117/12.2261946
Event: XIth Symposium on Laser Technology, 2016, Jastarnia, Poland
Abstract
The aim of the study was to investigate and compare photophysical properties of the most modern formulations used in the world – derivatives of: porphyrin, chlorines, bacteriochlorins, phthalocyanines and phenothiazines. Useful parameters of comparing the emission properties of various sensitizers groups are quantum yield of singlet oxygen generation (ΦT) and quantum yields of fluorescence (ΦF). The emission and excitation characteristics were appointed and shown as excitation – emission matrices (EX – EM). The influence of the monomerization degree of the pure hematoporphyrin (HP) on the quantum yield was also measured. Received quantum yield values of commonly used sensitizers are in the range 0.05 – 0.3 and efficiency values of singlet oxygen generation are 0.3 – 0.7. These values depend not only on the chemical structure of the compounds, but also on solvent polarity, temperature and concentration which is decisive for the monomerization degree.
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Magdalena Ligia Naurecka, Magdalena Ligia Naurecka, Bartosz Michał Sierakowski, Bartosz Michał Sierakowski, Mirosław Kwaśny, Mirosław Kwaśny, } "Spectroscopic properties of second generation photosensitizers for photo-diagnostics and photo-dynamic therapy", Proc. SPIE 10159, Laser Technology 2016: Progress and Applications of Lasers, 101590B (8 December 2016); doi: 10.1117/12.2261946; https://doi.org/10.1117/12.2261946
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