Polymer microfluidic bioreactor fabrication by means of gray scale lithography technique

Andrzej Sierakowski; Piotr Prokaryn; Rafał Dobrowolski; Anna Malinowska; Dariusz Szmigiel; Piotr Grabiec; Damian Trojanowski; Dagmara Jakimowicz; Jolanta Zakrzewska-Czerwinska

doi:10.1117/12.2245033

10 November 2016 Polymer microfluidic bioreactor fabrication by means of gray scale lithography technique

Andrzej Sierakowski, Piotr Prokaryn, Rafał Dobrowolski, Anna Malinowska, Dariusz Szmigiel, Piotr Grabiec, Damian Trojanowski, Dagmara Jakimowicz, Jolanta Zakrzewska-Czerwinska

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Proceedings Volume 10161, 14th International Conference on Optical and Electronic Sensors; 1016106 (2016) https://doi.org/10.1117/12.2245033
Event: 14th International Conference on Optical and Electronic Sensors, 2016, Gdansk, Poland

Abstract

In this paper we present a new method of polymer microfluidic bioreactor fabrication by means of a gray scale lithography technique. As a result of the gray scale lithography process the 3D model of the bioreactor is defined in photoresist. The obtained model serves as a sacrificial layer for the subsequent transfer of the 3D shape into the polymer material. The proposed method allows simultaneous definition of both the overall bioreactor geometry and the multi steps cell traps in a single photolithography step. Such microfluidic structure can be used for sorting cells based on their size. The developed solution significantly simplifies the production technology and reduces its costs in comparison to standard photolithography techniques.

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Andrzej Sierakowski, Piotr Prokaryn, Rafał Dobrowolski, Anna Malinowska, Dariusz Szmigiel, Piotr Grabiec, Damian Trojanowski, Dagmara Jakimowicz, and Jolanta Zakrzewska-Czerwinska "Polymer microfluidic bioreactor fabrication by means of gray scale lithography technique", Proc. SPIE 10161, 14th International Conference on Optical and Electronic Sensors, 1016106 (10 November 2016); https://doi.org/10.1117/12.2245033

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