16 May 2017 The driving regulators of the connectivity protein network of brain malignancies
Author Affiliations +
An important problem in modern therapeutics at the proteomic level remains to identify therapeutic targets in a plentitude of high-throughput data from experiments relevant to a variety of diseases. This paper presents the application of novel modern control concepts, such as pinning controllability and observability applied to the glioma cancer stem cells (GSCs) protein graph network with known and novel association to glioblastoma (GBM). The theoretical frameworks provides us with the minimal number of "driver nodes", which are necessary, and their location to determine the full control over the obtained graph network in order to provide a change in the network’s dynamics from an initial state (disease) to a desired state (non-disease). The achieved results will provide biochemists with techniques to identify more metabolic regions and biological pathways for complex diseases, to design and test novel therapeutic solutions.
© (2017) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Amirhessam Tahmassebi, Amirhessam Tahmassebi, Katja Pinker-Domenig, Katja Pinker-Domenig, Georg Wengert, Georg Wengert, Marc Lobbes, Marc Lobbes, Andreas Stadlbauer, Andreas Stadlbauer, Norelle C. Wildburger, Norelle C. Wildburger, Francisco J. Romero, Francisco J. Romero, Diego P. Morales, Diego P. Morales, Encarnacion Castillo, Encarnacion Castillo, Antonio Garcia, Antonio Garcia, Guillermo Botella, Guillermo Botella, Anke Meyer-Bäse, Anke Meyer-Bäse, } "The driving regulators of the connectivity protein network of brain malignancies", Proc. SPIE 10216, Smart Biomedical and Physiological Sensor Technology XIV, 1021605 (16 May 2017); doi: 10.1117/12.2263554; https://doi.org/10.1117/12.2263554

Back to Top