5 January 2017 Investigating different skin and gastrointestinal tract (GIT) pathologies ex vivo by autofluorescence spectroscopy and optical imaging
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Proceedings Volume 10226, 19th International Conference and School on Quantum Electronics: Laser Physics and Applications; 1022615 (2017) https://doi.org/10.1117/12.2261817
Event: International Conference and School on Quantum Electronics "Laser Physics and Applications" - ICSQE 2016, 2016, Sozopol, Bulgaria
Abstract
The skin neoplasias are on a second place in the world statistics of cancer incidence, and gastrointestinal tract (GIT) tumours are also in the “top ten” list. For the most of cutaneous and gastrointestinal tumours could be obtained better prognoses for patients, if an earlier and precise diagnostics procedure is applied. One of the most promising approaches for development of improved diagnostic techniques, is based on optical detection, and analysis of the signatures of biological tissues for detecting the presence of pathological alterations in the investigated objects.

It is important to develop and combine novel diagnostic techniques for an accurate early stage diagnosis to improve the chances for skin and GIT tumours treatment. Optical techniques are very promising methods for such noninvasive diagnosis of skin and mucosa tumours, possessing the advantages of deep imaging depth, high resolution, fast imaging speed, and noninvasive character of detection. In this study we combine autofluorescence spectroscopy and optical imaging techniques to develop more precise evaluation of the tissue pathologies investigated.

We obtain chromophore maps for GIT and cutaneous samples, with better visualization of the tumours borders and margins. In addition, fluorescence spectra give us information about the early changes in chromophores’ contents into the tissues during neoplasia growth.
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A. Zhelyazkova, I. Kuzmina, E. Borisova, N. Penkov, Ts. Genova, J. Spigulis, L. Avramov, "Investigating different skin and gastrointestinal tract (GIT) pathologies ex vivo by autofluorescence spectroscopy and optical imaging", Proc. SPIE 10226, 19th International Conference and School on Quantum Electronics: Laser Physics and Applications, 1022615 (5 January 2017); doi: 10.1117/12.2261817; https://doi.org/10.1117/12.2261817
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