16 May 2017 Nanomedical science and laser-driven particle acceleration: promising approaches in the prethermal regime
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Abstract
A major challenge of spatio-temporal radiation biomedicine concerns the understanding of biophysical events triggered by an initial energy deposition inside confined ionization tracks. This contribution deals with an interdisciplinary approach that concerns cutting-edge advances in real-time radiation events, considering the potentialities of innovating strategies based on ultrafast laser science, from femtosecond photon sources to advanced techniques of ultrafast TW laser-plasma accelerator. Recent advances of powerful TW laser sources (~1019 W cm-2) and laser-plasma interactions providing ultra-short relativistic particle beams in the energy domain 5-200 MeV open promising opportunities for the development of high energy radiation femtochemistry (HERF) in the prethermal regime of secondary low-energy electrons and for the real-time imaging of radiation-induced biomolecular alterations at the nanoscopic scale. New developments would permit to correlate early radiation events triggered by ultrashort radiation sources with a molecular approach of Relative Biological Effectiveness (RBE). These emerging research developments are crucial to understand simultaneously, at the sub-picosecond and nanometric scales, the early consequences of ultra-short-pulsed radiation on biomolecular environments or integrated biological entities. This innovating approach would be applied to biomedical relevant concepts such as the emerging domain of real-time nanodosimetry for targeted pro-drug activation and pulsed radio-chimiotherapy of cancers.
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Y. A. Gauduel, "Nanomedical science and laser-driven particle acceleration: promising approaches in the prethermal regime", Proc. SPIE 10239, Medical Applications of Laser-Generated Beams of Particles IV: Review of Progress and Strategies for the Future, 1023907 (16 May 2017); doi: 10.1117/12.2264974; https://doi.org/10.1117/12.2264974
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