30 May 2017 Integration of a capacitive pressure sensing system into the outer catheter wall for coronary artery FFR measurements
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Abstract
The deadliest disease in the world is coronary artery disease (CAD), which is related to a narrowing (stenosis) of blood vessels due to fatty deposits, plaque, on the arterial walls. The level of stenosis in the coronary arteries can be assessed by Fractional Flow Reserve (FFR) measurements. This involves determining the ratio between the maximum achievable blood flow in a diseased coronary artery and the theoretical maximum flow in a normal coronary artery. The blood flow is represented by a pressure drop, thus a pressure wire or pressure sensor integrated in a catheter can be used to calculate the ratio between the coronary pressure distal to the stenosis and the normal coronary pressure. A 2 Fr (0.67mm) outer diameter catheter was used, which required a high level of microelectronics miniaturisation to fit a pressure sensing system into the outer wall. The catheter has an eccentric guidewire lumen with a diameter of 0.43mm, which implies that the thickest catheter wall section provides less than 210 microns height for flex assembly integration consisting of two dies, a capacitive MEMS pressure sensor and an ASIC. In order to achieve this a very thin circuit flex was used, and the two chips were thinned down to 75 microns and flip chip mounted face down on the flex. Many challenges were involved in obtaining a flex layout that could wrap into a small tube without getting the dies damaged, while still maintaining enough flexibility for the catheter to navigate the arterial system.
Conference Presentation
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Frank Stam, Frank Stam, Heikki Kuisma, Heikki Kuisma, Feng Gao, Feng Gao, Jaakko Saarilahti, Jaakko Saarilahti, David Gomes Martins, David Gomes Martins, Anu Kärkkäinen, Anu Kärkkäinen, Brendan Marrinan, Brendan Marrinan, Sebastian Pintal, Sebastian Pintal, } "Integration of a capacitive pressure sensing system into the outer catheter wall for coronary artery FFR measurements", Proc. SPIE 10247, Bio-MEMS and Medical Microdevices III, 1024703 (30 May 2017); doi: 10.1117/12.2263779; https://doi.org/10.1117/12.2263779
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