Wavefront correction enables vibrational imaging of bacteria with multimode fibre probes

Ivan Gusachenko; Mingzhou Chen; Kishan Dholakia

doi:10.1117/12.2274974

18 April 2017 Wavefront correction enables vibrational imaging of bacteria with multimode fibre probes

Ivan Gusachenko; Mingzhou Chen; Kishan Dholakia

Author Affiliations +

Proceedings Volume 10251, Biomedical Imaging and Sensing Conference; 1025104 (2017) https://doi.org/10.1117/12.2274974
Event: SPIE Technologies and Applications of Structured Light, 2017, Yokohama, Japan

Abstract

Raman spectroscopy is a valuable tool for non-invasive and label-free identification of sample chemical composition. Recently a few miniaturized optical probes emerged driven by the need to address areas of difficult access, such as in endoscopy. However, imaging modality is still out of reach for most of them. Separately, recent advances in wavefront shaping enabled different microscopies to be applied in various complex media including multimode fibers. Here we present the first and thinnest to date Raman fiber imaging probe based on wavefront shaping through a single multimode fiber without use of any additional optics. We image agglomerates of bacteria and pharmaceuticals to demonstrate the capability of our method. This work paves the way towards compact and flexible Raman endoscopy.

Citation Download Citation

Ivan Gusachenko, Ivan Gusachenko, Mingzhou Chen, Mingzhou Chen, Kishan Dholakia, Kishan Dholakia, } "Wavefront correction enables vibrational imaging of bacteria with multimode fibre probes", Proc. SPIE 10251, Biomedical Imaging and Sensing Conference, 1025104 (18 April 2017); doi: 10.1117/12.2274974; https://doi.org/10.1117/12.2274974

ACCESS THE FULL ARTICLE

PERSONAL SIGN IN
Full access may be available with your subscription

Email or Username Forgot your username?

Password Forgot your password?

Show

Remember Email/Username on this computer

Remember Password

No SPIE account? Create an account
or Institutional Sign In via Shibboleth

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $14.40

Non-members: $18.00 ADD TO CART

Show All Keywords

Keywords/Phrases

Search In:

Publication Years