18 April 2017 Label-free characterization of degenerative changes in articular cartilage by Raman spectroscopy
Author Affiliations +
Proceedings Volume 10251, Biomedical Imaging and Sensing Conference; 1025108 (2017) https://doi.org/10.1117/12.2275047
Event: SPIE Technologies and Applications of Structured Light, 2017, Yokohama, Japan
Abstract
Osteoarthritis (OA) is very common joint disease in the aging population. Main symptom of OA is accompanied by degenerative changes of articular cartilage. Raman spectroscopy is a label-free technique which enables to analyze molecular composition in degenerative cartilage. We generated an animal OA model surgically induced by knee joint instability and performed Raman spectroscopic analysis for the articular cartilage. In the result, Raman spectral data of the articular cartilage showed drastic changes in comparison between OA and control side. The relative intensity of phosphate band increases in the degenerative cartilage.
© (2017) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Yusuke Oshima, Yusuke Oshima, Mayu Akehi, Mayu Akehi, Hiroshi Kiyomatsu, Hiroshi Kiyomatsu, Hiromasa Miura, Hiromasa Miura, } "Label-free characterization of degenerative changes in articular cartilage by Raman spectroscopy", Proc. SPIE 10251, Biomedical Imaging and Sensing Conference, 1025108 (18 April 2017); doi: 10.1117/12.2275047; https://doi.org/10.1117/12.2275047
PROCEEDINGS
2 PAGES


SHARE
Back to Top