18 April 2017 Evaluation of bone quality in osteoporosis model mice by Raman spectroscopy
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Proceedings Volume 10251, Biomedical Imaging and Sensing Conference; 102511D (2017) https://doi.org/10.1117/12.2274980
Event: SPIE Technologies and Applications of Structured Light, 2017, Yokohama, Japan
To evaluate the bone quality in the osteoporosis, we generated sciatic nerve resection (NX) mice as an osteoporosis model and analyzed by Raman spectroscopy. Raman spectra were measured in anterior cortical surface of the proximal tibia at 5 points in each bone. After that, the samples were fixed with 70% ethanol. We then performed DXA and μCT measurement. Raman peak intensity ratios were significantly different between NX and Control. Those changes in the Raman peak intensity ratios may reflect loss of bone quality in the osteoporosis model. Raman spectroscopy is a promising technique for measuring the bone quality and bone strength.
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Yasumitsu Ishimaru, Yasumitsu Ishimaru, Yusuke Oshima, Yusuke Oshima, Yuuki Imai, Yuuki Imai, Tadahiro Iimura, Tadahiro Iimura, Sota Takanezawa, Sota Takanezawa, Kazunori Hino, Kazunori Hino, Hiromasa Miura, Hiromasa Miura, } "Evaluation of bone quality in osteoporosis model mice by Raman spectroscopy", Proc. SPIE 10251, Biomedical Imaging and Sensing Conference, 102511D (18 April 2017); doi: 10.1117/12.2274980; https://doi.org/10.1117/12.2274980

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