Study of targeted-treatment on colon cancer cell via spectroscopic imaging ellipsometry

Yu-Da Chen; Hao Yun Hsu; Mai Ibrahim Khaleel; Ching-Hsiang Chan; Yia-Chung Chang; Chien-Hsun Wu; Han-Chung Wu

doi:10.1117/12.2267971

18 April 2017 Study of targeted-treatment on colon cancer cell via spectroscopic imaging ellipsometry

Yu-Da Chen, Hao Yun Hsu, Mai Ibrahim Khaleel, Ching-Hsiang Chan, Yia-Chung Chang, Chien-Hsun Wu, Han-Chung Wu

Proceedings Volume 10251, Biomedical Imaging and Sensing Conference; 102511L (2017) https://doi.org/10.1117/12.2267971
Event: SPIE Technologies and Applications of Structured Light, 2017, Yokohama, Japan

Abstract

We present the enhancement of targeted treatment on colon cancer cell via microscopic imaging ellipsometry (MIE). All spectroscopic MIE signals on 5μm×5μm area in visible range are captured within the modified Optrel MULTISKOP system. Colon cancer cells are cultured in Bottom-up Millicell EZ SLIDE 4-well structure under the environment (37°C, 10% CO₂). Original single colon cancer cell, single colon cancer cell under untargeted-treatment, and single colon cancer cell under targeted-treatment are studied by specular-reflective mode and off-specular scattering mode in this experiment. Some polarization-related and phase-related MIE images are analyzed to reveal the improvement of targeted-treatment by observing changes in specular and off-specular reflectance and absorption.

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Yu-Da Chen, Hao Yun Hsu, Mai Ibrahim Khaleel, Ching-Hsiang Chan, Yia-Chung Chang, Chien-Hsun Wu, and Han-Chung Wu "Study of targeted-treatment on colon cancer cell via spectroscopic imaging ellipsometry", Proc. SPIE 10251, Biomedical Imaging and Sensing Conference, 102511L (18 April 2017); https://doi.org/10.1117/12.2267971

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