Light propagation analysis for fluorescence measurements of a molecular probe in the brain

Kota Asai; Takuya Togashi; Eiji Okada

doi:10.1117/12.2274896

18 April 2017 Light propagation analysis for fluorescence measurements of a molecular probe in the brain

Kota Asai, Takuya Togashi, Eiji Okada

Proceedings Volume 10251, Biomedical Imaging and Sensing Conference; 102511S (2017) https://doi.org/10.1117/12.2274896
Event: SPIE Technologies and Applications of Structured Light, 2017, Yokohama, Japan

Abstract

Light propagation in the slab head model that consists of five types of tissues was calculated to estimate the fluorescent intensity emerged from a molecular probe in the brain by a Monte Carlo simulation. The thickness of the scalp, skull and cerebrospinal fluid layer was varied to analyze the influence of the thickness of the superficial tissues on the fluorescent intensity detected on the scalp surface. The fluorescent intensity is exponentially reduced with increasing the depth of the brain surface. The thickness of the cerebrospinal fluid layer more significantly affects the fluorescent intensity than that of the scalp and skull.

Citation Download Citation

Kota Asai, Takuya Togashi, and Eiji Okada "Light propagation analysis for fluorescence measurements of a molecular probe in the brain", Proc. SPIE 10251, Biomedical Imaging and Sensing Conference, 102511S (18 April 2017); https://doi.org/10.1117/12.2274896

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