Prospects of phthalocyanines as photosensitizers for the photodynamic therapy of cancer

Johan E. van Lier

doi:10.1117/12.2283670

21 January 1990 Prospects of phthalocyanines as photosensitizers for the photodynamic therapy of cancer

Johan E. van Lier

Proceedings Volume 10306, Future Directions and Applications in Photodynamic Therapy; 1030608 (1990) https://doi.org/10.1117/12.2283670
Event: SPIE Institutes for Advanced Optical Technologies 6, 1990, San Diego, California, United States

Abstract

Metallophthalocyanines and naphthalocyanines are under intensive study as second generation photosensitizers for PDT. They have attractive photophysical and chemical properties including strong absorption maxima at wavelengths where tissues provide optimal light transmissions, good capacity to generate singlet oxygen and facile chemical accessibility. Their photophysical properties are mainly determined by the nature of the central metal ion whereas ring substituents and axial ligands on the metal ion modulate solubility, tendencies to aggregate or associate with biomolecules, cell penetrating properties and the pharmacokinetics of the dyes. The availability of series of differently substituted metallophtha- locyanines and naphthalocyanines provides for the opportunity to assess structure- activity relationships with various parameters of importance in the overall out- come of PDT, an approach which could guide future syntheses of improved photosen- sitizers for the photodynamic therapy of cancer.

Citation Download Citation

Johan E. van Lier "Prospects of phthalocyanines as photosensitizers for the photodynamic therapy of cancer", Proc. SPIE 10306, Future Directions and Applications in Photodynamic Therapy, 1030608 (21 January 1990); https://doi.org/10.1117/12.2283670

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