21 January 1990 New approaches to photochemotherapy: cationic sensitizers and multi-agent combination therapies
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Proceedings Volume 10306, Future Directions and Applications in Photodynamic Therapy; 103060E (1990) https://doi.org/10.1117/12.2283676
Event: SPIE Institutes for Advanced Optical Technologies 6, 1990, San Diego, California, United States
Abstract
"Second generation" photochemotherapies might employ a multiagent approach using cationic photosensitizers which selectively target tumor cells together with anionic photosensitizers which act on blood vessels. Combination photochemotherapies might also include glycolysis inhibitors and/or hyperthermia to rationally enhance light-induced killing and still maintain tumor selectivity. Some unresolved issues are also discussed: We generally do not understand the biological bases for tumor selectivity and photochemotherapeutic efficacy. We need to determine the desirability of absolute malignant cell specificity. Both in vitro and in vivo test systems should be improved and standardized, and their (ir)relevance to clinical PCT carefully examined. More mechanistic data should be obtained from ongoing and future clinical trials. Finally, we need to better define the critical biochemical and cellular mechanisms of cell injury and death, and better understand why therapy fails.
© (1990) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Allan R. Oseroff, Allan R. Oseroff, } "New approaches to photochemotherapy: cationic sensitizers and multi-agent combination therapies", Proc. SPIE 10306, Future Directions and Applications in Photodynamic Therapy, 103060E (21 January 1990); doi: 10.1117/12.2283676; https://doi.org/10.1117/12.2283676
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