On the physical rationale of photodynamic therapy

Lars O. Svaasand

doi:10.1117/12.2283680

21 January 1990 On the physical rationale of photodynamic therapy

Lars O. Svaasand

Proceedings Volume 10306, Future Directions and Applications in Photodynamic Therapy; 103060I (1990) https://doi.org/10.1117/12.2283680
Event: SPIE Institutes for Advanced Optical Technologies 6, 1990, San Diego, California, United States

Abstract

The physical principles of dosimetry for photodynamic therapy are discussed. The presentation emphasizes a discussion of prognosticated maximum obtainable depth of tumor necrosis and of expected maximum depth of selective necrosis, i.e. the maximum depth which can be obtained before normal tissue within the light field at the surface is destroyed at the same rate as the neoplastic cells at the given depth into the tumor. These parameters are discussed in terms of bleaching, retention and clearance of the photosensitizer and of optical properties of the tissue.

Citation Download Citation

Lars O. Svaasand "On the physical rationale of photodynamic therapy", Proc. SPIE 10306, Future Directions and Applications in Photodynamic Therapy, 103060I (21 January 1990); https://doi.org/10.1117/12.2283680

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