In a vast amount of medical diseases the biochemical and physiological changes of soft tissues are hardly detectable by conventional techniques of diagnostic imaging (x- ray, ultrasound, computer tomography, and MRI). The detectivity is low and the technical efforts are tremendous. On the other hand these pathologic variations induce significant changes of the optical tissue parameters which can be detected. The corresponding variations of the scattered light can most easily be detected and evaluated by infrared diaphanoscopy, even on optical thick tissue slices.
J. Beuthan, J. Beuthan,
"Techniques A: continuous waves", Proc. SPIE 10311, Medical Optical Tomography: Functional Imaging and Monitoring, 103110G (5 August 1993); doi: 10.1117/12.2283761; https://doi.org/10.1117/12.2283761