Photodynamic therapy induces intracellular calcium release in human glioblastoma cells: helping thy neighbor...to live or die

Stuart K. Bisland

doi:10.1117/12.2283890

29 August 2017 Photodynamic therapy induces intracellular calcium release in human glioblastoma cells: helping thy neighbor...to live or die

Stuart K. Bisland

Author Affiliations +

Proceedings Volume 10313, Opto-Canada: SPIE Regional Meeting on Optoelectronics, Photonics, and Imaging; 103132M (2017) https://doi.org/10.1117/12.2283890
Event: Opto-Canada: SPIE Regional Meeting on Optoelectronics, Photonics, and Imaging, 2002, Ottawa, Ontario, Canada

Abstract

Photodynamic therapy (PDT) has proven itself worthy of continued research as a viable treatment of certain neoplastic growths (1). The past decade has seen a deluge of research papers describing the use of PDT for a wide array of cellular and animal models. More recent studies indicate an increasing emphasis towards understanding the mechanisms of PDT and the various parameters that govern and predict its overall efficacy. Many questions remain to be answered with regards to the amount of drug and light that should be administered in order to ensure optimal photophysical activation of the photosensitizer. The ideal photodynamic treatment would achieve complete and selective ablation of the tumour following minimal drug and light. This has yet to be reported. Being able to extrapolate the mechanistics of light entering and activating the photosensitizer at the tissue level down to the subcellular level is no small task and will depend on the type of tissue and cells being targeted (2). Our studies focus on the subcellular effects of PDT, in particular the role of calcium and the events that lead up to PDT-mediated induction of apoptosis.

Citation Download Citation

Stuart K. Bisland "Photodynamic therapy induces intracellular calcium release in human glioblastoma cells: helping thy neighbor...to live or die", Proc. SPIE 10313, Opto-Canada: SPIE Regional Meeting on Optoelectronics, Photonics, and Imaging, 103132M (29 August 2017); https://doi.org/10.1117/12.2283890

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