29 August 2017 In vivo imaging of colonic tumours with a near-infrared fluorescent probe targeted against a tumour-associated-mucin in a human colon cancer xenograft mouse model
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Proceedings Volume 10313, Opto-Canada: SPIE Regional Meeting on Optoelectronics, Photonics, and Imaging; 1031334 (2017) https://doi.org/10.1117/12.2283908
Event: Opto-Canada: SPIE Regional Meeting on Optoelectronics, Photonics, and Imaging, 2002, Ottawa, Ontario, Canada
Abstract
Purpose: Conventional endoscopic imaging in human colon detects large hyperplastic and adenomatous polyps (<5mm diam). However, detecting smaller early neoplastic lesions and flat adenomas is problematic. To improve the detection of such lesions we assessed the utility of fluorescence contrast agents for enhancing contrast between normal and abnormal tissues. To this end, a near infrared (NIR) fluorescent dye conjugated to a monoclonal antibody (MAb) with high affinity for a tumour-associated-glycoprotein (TAG72) antigen commonly found in colon tumours was studied as a potential fluorescence contrast agent.
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Ralph S. DaCosta, Ralph S. DaCosta, } "In vivo imaging of colonic tumours with a near-infrared fluorescent probe targeted against a tumour-associated-mucin in a human colon cancer xenograft mouse model", Proc. SPIE 10313, Opto-Canada: SPIE Regional Meeting on Optoelectronics, Photonics, and Imaging, 1031334 (29 August 2017); doi: 10.1117/12.2283908; https://doi.org/10.1117/12.2283908
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