29 August 2017 Statistical parametric imaging of heart function with ECG-gated perfusion scans
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Proceedings Volume 10313, Opto-Canada: SPIE Regional Meeting on Optoelectronics, Photonics, and Imaging; 103133T (2017) https://doi.org/10.1117/12.2283933
Event: Opto-Canada: SPIE Regional Meeting on Optoelectronics, Photonics, and Imaging, 2002, Ottawa, Ontario, Canada
Abstract
Computer assisted interpretation programs are used widely for the initial diagnosis of coronary artery disease, but are not yet available to help monitor the progression of disease over time. We developed the direct paired comparison (DPC) method to assess the statistical significance of changes in serial positron tomography (PET) perfusion scans, which is now adapted for serial ECG-gated single photon tomography (SPECT). The purpose of this study was to evaluate the specificity and sensitivity of DPC for the detection of significant changes in perfusion and wall-thickening with gated SPECT. Scan data were simulated with uniform perfusion (100%), wall-thickening (20%), and Gaussian noise (20%). Gated count density curves were fit with an eccentric sinusoidal thickening model. Perfusion and wall-thickening differences between baseline and repeat data (n=500) were analyzed using DPC under the null hypothesis (Ho) to assess specificity. Measured 16-gate data (n=5) were then split into 8-gate pairs to verify specificity.
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Robert Hart, "Statistical parametric imaging of heart function with ECG-gated perfusion scans", Proc. SPIE 10313, Opto-Canada: SPIE Regional Meeting on Optoelectronics, Photonics, and Imaging, 103133T (29 August 2017); doi: 10.1117/12.2283933; https://doi.org/10.1117/12.2283933
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