23 April 2017 Biomolecular detection with an interferometric microfiber-capillary optofluidic sensor
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Proceedings Volume 10323, 25th International Conference on Optical Fiber Sensors; 103230Y (2017) https://doi.org/10.1117/12.2264772
Event: 25th International Conference on Optical Fiber Sensors, 2017, Jeju, Korea, Republic of
Abstract
We have developed a chip-scale optofluidic sensor for biomolecular detection, by tapering laterally aligned silica microfiber and capillary to form a modal interferometer. With the pre-immobilization of DNA probes, the sensor is capable of selectively detecting single-stranded microRNA-let7a (molecular weight: 6.5 k) by measuring the spectral shift of the interferometric spectrum. A log-linear response from 2 nM to 20 μM and a minimum detectable concentration of 212 pM (1.43 ng/mL) have been achieved. The sensor is promising for future diagnosis applications due to its high sensitivity, resistance to environmental perturbations, improved portability, and intrinsic connection to fiber optic measurement.
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Lili Liang, Lili Liang, Long Jin, Long Jin, Bai-Ou Guan, Bai-Ou Guan, } "Biomolecular detection with an interferometric microfiber-capillary optofluidic sensor", Proc. SPIE 10323, 25th International Conference on Optical Fiber Sensors, 103230Y (23 April 2017); doi: 10.1117/12.2264772; https://doi.org/10.1117/12.2264772
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