The influence of local pressure on evaluation parameters of skin blood perfusion and fluorescence

E. A. Zherebtsov; K. Y. Kandurova; E. S. Seryogina; I. O. Kozlov; V. V. Dremin; A. I. Zherebtsova; A. V. Dunaev; I. Meglinski

doi:10.1117/12.2267957

24 March 2017 The influence of local pressure on evaluation parameters of skin blood perfusion and fluorescence

E. A. Zherebtsov, K. Y. Kandurova, E. S. Seryogina, I. O. Kozlov, V. V. Dremin, A. I. Zherebtsova, A. V. Dunaev, I. Meglinski

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Proceedings Volume 10336, Saratov Fall Meeting 2016: Optical Technologies in Biophysics and Medicine XVIII; 1033608 (2017) https://doi.org/10.1117/12.2267957
Event: Saratov Fall Meeting 2016: Fourth International Symposium on Optics and Biophotonics, 2016, Saratov, Russian Federation

Abstract

This article presents the results of the study of the pressure applied on optical diagnostic probes as a significant factor affecting the results of measurements. During stepwise increasing and decreasing of local pressure on skin we conducted measurements using the methods of laser Doppler flowmetry and fluorescence spectroscopy. It was found out that pressure on optical probe has sufficient impact on skin microcirculation to affect registered fluorescence intensity. Data obtained in this study are of interest for design and development of diagnostic technologies for wearable devices. This data will also inform further investigation into issues of compensation of blood absorption influence on fluorescence spectrum, allowing increased accuracy and reproducibility of measurements by fluorescence spectroscopy methods in optical diagnosis.

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E. A. Zherebtsov, K. Y. Kandurova, E. S. Seryogina, I. O. Kozlov, V. V. Dremin, A. I. Zherebtsova, A. V. Dunaev, and I. Meglinski "The influence of local pressure on evaluation parameters of skin blood perfusion and fluorescence", Proc. SPIE 10336, Saratov Fall Meeting 2016: Optical Technologies in Biophysics and Medicine XVIII, 1033608 (24 March 2017); https://doi.org/10.1117/12.2267957

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