24 March 2017 Investigation of flavonoid influence on peroxidation processes intensity in the blood
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Proceedings Volume 10336, Saratov Fall Meeting 2016: Optical Technologies in Biophysics and Medicine XVIII; 103360X (2017) https://doi.org/10.1117/12.2268336
Event: Saratov Fall Meeting 2016: Fourth International Symposium on Optics and Biophotonics, 2016, Saratov, Russian Federation
Abstract
Influence of flavonoids on the intensity of peroxidation processes in the blood is investigated by numerical modeling and by experiment in vivo. As an example we consider the effects of flavonoid-containing extract of Helichrysum arenarium L. with antitumor activity on serum of rats with transplanted liver cancer PC-1. It was found that the content of malondialdehyde, lipid hydroperoxides and average mass molecules were decreased in animals with transplanted liver cancer after intramuscular and oral administration of Helichrysum arenarium L extract in a dose of 1000 mg/mL. The extract reduces the intensity of lipid peroxidation processes in animals. The compound formation possibility of flavonoids and products of lipid peroxidation is investigated by numerical simulations. Using the density functional theory method of molecular modeling, we analyze hydrogen bonds formation and their influence on IR - spectra and structure of molecular complex which is formed due to interaction between flavonoids and products of lipid peroxidation processes on example of naringine and malondialdehyde. We have found that naringine can form a steady molecular complex with malondialdehyde by hydrogen bonds formation. Thus, the application of Helichrysum arenarium L. extract for suppression processes of lipid peroxidation and activation of enzymatic and non-enzymatic antioxidant systems is promising.
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N. A. Navolokin, N. A. Navolokin, D. A. Mudrak, D. A. Mudrak, I. L. Plastun, I. L. Plastun, A. B. Bucharskaya, A. B. Bucharskaya, K. E. Agandeeva, K. E. Agandeeva, A. V. Ivlichev, A. V. Ivlichev, S. A. Tychina, S. A. Tychina, G. A. Afanasyeva, G. A. Afanasyeva, N. V. Polukonova, N. V. Polukonova, G. N. Maslyakova, G. N. Maslyakova, } "Investigation of flavonoid influence on peroxidation processes intensity in the blood ", Proc. SPIE 10336, Saratov Fall Meeting 2016: Optical Technologies in Biophysics and Medicine XVIII, 103360X (24 March 2017); doi: 10.1117/12.2268336; https://doi.org/10.1117/12.2268336
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