Evaluating changes in brain vasculature of murine embryos in utero due to maternal alcohol consumption using optical coherence tomography

Raksha Raghunathan; Chen Wu; Manmohan Singh; Chih-Hao Liu; Rajesh C. Miranda; Kirill V. Larin

doi:10.1117/12.2277143

29 April 2017 Evaluating changes in brain vasculature of murine embryos in utero due to maternal alcohol consumption using optical coherence tomography

Raksha Raghunathan, Chen Wu, Manmohan Singh, Chih-Hao Liu, Rajesh C. Miranda, Kirill V. Larin

Author Affiliations +

Proceedings Volume 10340, International Conference on Biophotonics V; 103401G (2017) https://doi.org/10.1117/12.2277143
Event: International Conference on Biophotonics V, 2017, Perth, Australia

Abstract

Fetal Alcohol Syndrome (FAS) refers to the broad spectrum of developmental and behavioral effects caused due to prenatal alcohol exposure (PAE).

Wide range of abnormalities vary depending on the amount of alcohol consumed and the period of consumption during gestation.

PAE during early stages of pregnancy is very common. However a large number of women continue to consume alcohol even during the second trimester, a critical period for fetal neurogenesis and angiogenesis.

Optical coherence tomography (OCT) has shown to be extremely useful in embryonic imaging.

Our previous work showed that OCT is capable of quantitative assessment of ventriculomegaly caused by maternal alcohol consumption.

Although structural changes and changes in blood flow in the fetal brain after maternal alcohol consumption have been studied, acute vasculature changes are not well documented.

Speckle variance OCT (SVOCT), is a functional extension of OCT that has been used to study vasculature development in embryos.

We use SVOCT, to detect vasculature changes in the embryonic brain in utero, minutes after maternal alcohol consumption.

Citation Download Citation

Raksha Raghunathan, Chen Wu, Manmohan Singh, Chih-Hao Liu, Rajesh C. Miranda, and Kirill V. Larin "Evaluating changes in brain vasculature of murine embryos in utero due to maternal alcohol consumption using optical coherence tomography", Proc. SPIE 10340, International Conference on Biophotonics V, 103401G (29 April 2017); https://doi.org/10.1117/12.2277143

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