25 August 2017 Electrolyte gated TFT biosensors based on the Donnan's capacitance of anchored biomolecules
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Abstract
Biodetection using electrolyte gated field effect transistors has been mainly correlated to charge modulated transduction. Therefore, such platforms are designed and studied for limited applications involving relatively small charged species and much care is taken in the operating conditions particularly pH and salt concentration (ionic strength). However, there are several reports suggesting that the device conductance can also be very sensitive towards variations in the capacitance coupling. Understanding the sensing mechanism is important for further exploitation of these promising sensors in broader range of applications. In this paper, we present a thorough and in depth study of a multilayer protein system coupled to an electrolyte gated transistor. It is demonstrated that detection associated to a binding event taking place at a distance of 30 nm far from the organic semiconductor-electrolyte interface is possible and the device conductance is dominated by Donnan’s capacitance of anchored biomolecules.
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Kyriaki Manoli, Kyriaki Manoli, Gerardo Palazzo, Gerardo Palazzo, Eleonora Macchia, Eleonora Macchia, Amber Tiwari, Amber Tiwari, Cinzia Di Franco, Cinzia Di Franco, Gaetano Scamarcio, Gaetano Scamarcio, Pietro Favia, Pietro Favia, Antonia Mallardi, Antonia Mallardi, Luisa Torsi, Luisa Torsi, } "Electrolyte gated TFT biosensors based on the Donnan's capacitance of anchored biomolecules", Proc. SPIE 10364, Organic Sensors and Bioelectronics X, 103640J (25 August 2017); doi: 10.1117/12.2274940; https://doi.org/10.1117/12.2274940
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