We have developed an innovative lighting system prototype for a patient room application that integrates a multi-channel luminaire platform into indoor general area luminaires. This system is energy efficient, spectrally tunable, and supports the visual and nonvisual needs of occupants. We evaluated the performance of two separate multichannel platforms in different luminaire types, using a unique color-processing algorithm. The LED modeling and simulations enabled optimization of spectral power distributions, color, light output, and efficacy. This paper discusses the complicated results of SPDs developed for the patient room application, especially how they are effective for positively supporting the human visual and non-visual (circadian) systems. Additionally, application measurements demonstrate the large impact of the application space on the resulting SPD of a luminaire, calling into question the feasibility of using traditional field measurements to validate luminaire performance.