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28 July 2017Assessment of the status of onchocerciasis worms with DRS: proposal of a standardized measurement protocol
Anne Planat-Chrétien,1 M. Berger,1 Samuel Wanji,2 Michel Boussinesq,3 Belen Pedrique,4 Jean-Marc Dinten1
1CEA-LETI (France) 2Univ. of Buea (Cameroon) 3Institut de Recherche pour le Développement (France) 4Drugs for Neglected Diseases Initiative (Switzerland)
In the present work, we show the capacity of spatially resolved Diffuse Reflectance Spectroscopy (DRS) to identify live and dead worms in ex vivo Onchocerca ochengi nodules. It demonstrates the potential of DRS to diagnose the worm state and to monitor the effect of a drug on macrofilariae. These results have been obtained in constrained conditions, leading to the proposal of a rigorous acquisition and analysis protocol that may contribute to standardized measures in diffuse optics.
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Anne Planat-Chrétien, M. Berger, Samuel Wanji, Michel Boussinesq, Belen Pedrique, Jean-Marc Dinten, "Assessment of the status of onchocerciasis worms with DRS: proposal of a standardized measurement protocol," Proc. SPIE 10412, Diffuse Optical Spectroscopy and Imaging VI, 104120I (28 July 2017); https://doi.org/10.1117/12.2286051