Assessment of the status of onchocerciasis worms with DRS: proposal of a standardized measurement protocol

Anne Planat-Chrétien; M. Berger; Samuel Wanji; Michel Boussinesq; Belen Pedrique; Jean-Marc Dinten

doi:10.1117/12.2286051

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28 July 2017 Assessment of the status of onchocerciasis worms with DRS: proposal of a standardized measurement protocol

Anne Planat-Chrétien, M. Berger, Samuel Wanji, Michel Boussinesq, Belen Pedrique, Jean-Marc Dinten

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Proceedings Volume 10412, Diffuse Optical Spectroscopy and Imaging VI; 104120I (2017) https://doi.org/10.1117/12.2286051
Event: European Conferences on Biomedical Optics, 2017, Munich, Germany

Abstract

In the present work, we show the capacity of spatially resolved Diffuse Reflectance Spectroscopy (DRS) to identify live and dead worms in ex vivo Onchocerca ochengi nodules. It demonstrates the potential of DRS to diagnose the worm state and to monitor the effect of a drug on macrofilariae. These results have been obtained in constrained conditions, leading to the proposal of a rigorous acquisition and analysis protocol that may contribute to standardized measures in diffuse optics.

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Anne Planat-Chrétien, M. Berger, Samuel Wanji, Michel Boussinesq, Belen Pedrique, and Jean-Marc Dinten "Assessment of the status of onchocerciasis worms with DRS: proposal of a standardized measurement protocol", Proc. SPIE 10412, Diffuse Optical Spectroscopy and Imaging VI, 104120I (28 July 2017); https://doi.org/10.1117/12.2286051

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