28 July 2017 Monitoring of caffeine consumption effect on skin blood properties by diffuse reflectance spectroscopy
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Caffeine is the most widely consumed psychoactive substance in the world. It affects many tissues and organs, in particular central nervous system, heart, and blood vessels. The effect of caffeine on vascular smooth muscle cells is an initial transient contraction followed by significant vasodilatation. In this study we investigate the use of diffuse reflectance spectroscopy (DRS) for monitoring of vascular changes in human skin induced by caffeine consumption. DRS spectra were recorded on volar sides of the forearms of ten healthy volunteers at time delays of 0, 30, 60, 120, and 180 minutes after consumption of caffeine, while one subject served as a negative control. Analytical diffusion approximation solutions for diffuse reflectance from three-layer structures were used to assess skin composition (e.g., dermal blood volume fraction and oxygen saturation) by fitting to experimental data. The results demonstrate that cutaneous vasodynamics induced by caffeine consumption can be monitored by DRS, while changes in the control subject not consuming caffeine were insignificant.
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Matija Milanic, Matija Milanic, Ana Marin, Ana Marin, Jost Stergar, Jost Stergar, Nina Verdel, Nina Verdel, Boris Majaron, Boris Majaron, } "Monitoring of caffeine consumption effect on skin blood properties by diffuse reflectance spectroscopy", Proc. SPIE 10412, Diffuse Optical Spectroscopy and Imaging VI, 1041215 (28 July 2017); doi: 10.1117/12.2286140; https://doi.org/10.1117/12.2286140

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