Analysis of hemodynamics in human skin using photothermal radiometry and diffuse reflectance spectroscopy

Nina Verdel; Ana Marin; Luka Vidovič; Matija Milanič; Boris Majaron

doi:10.1117/12.2286043

28 July 2017 Analysis of hemodynamics in human skin using photothermal radiometry and diffuse reflectance spectroscopy

Nina Verdel, Ana Marin, Luka Vidovič, Matija Milanič, Boris Majaron

Proceedings Volume 10413, Novel Biophotonics Techniques and Applications IV; 104130O (2017) https://doi.org/10.1117/12.2286043
Event: European Conferences on Biomedical Optics, 2017, Munich, Germany

Abstract

We present a novel methodology for quantitative analysis of hemodynamics in human skin in vivo. Our approach combines pulsed photothermal radiometry (i.e., time-resolved measurements of midinfrared emission from sample surface after exposure to a short light pulse) and diffuse reflectance spectroscopy in visible part of the spectrum. Experimental data are fitted with predictions of a numerical model of light transport in a four-layer skin model (i.e., inverse Monte Carlo), which allows assessment of the layer thicknesses, chromophore contents (e.g., melanin, oxy- and deoxy-hemoglobin), as well as scattering properties. The performance is tested in comparison analysis of healthy skin before and during application of a blood pressure cuff (at 200 mm Hg) for 5 minutes.

Citation Download Citation

Nina Verdel, Ana Marin, Luka Vidovič, Matija Milanič, and Boris Majaron "Analysis of hemodynamics in human skin using photothermal radiometry and diffuse reflectance spectroscopy", Proc. SPIE 10413, Novel Biophotonics Techniques and Applications IV, 104130O (28 July 2017); https://doi.org/10.1117/12.2286043

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