28 July 2017 Analysis of hemodynamics in human skin using photothermal radiometry and diffuse reflectance spectroscopy
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Abstract
We present a novel methodology for quantitative analysis of hemodynamics in human skin in vivo. Our approach combines pulsed photothermal radiometry (i.e., time-resolved measurements of midinfrared emission from sample surface after exposure to a short light pulse) and diffuse reflectance spectroscopy in visible part of the spectrum. Experimental data are fitted with predictions of a numerical model of light transport in a four-layer skin model (i.e., inverse Monte Carlo), which allows assessment of the layer thicknesses, chromophore contents (e.g., melanin, oxy- and deoxy-hemoglobin), as well as scattering properties. The performance is tested in comparison analysis of healthy skin before and during application of a blood pressure cuff (at 200 mm Hg) for 5 minutes.
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Nina Verdel, Nina Verdel, Ana Marin, Ana Marin, Luka Vidovič, Luka Vidovič, Matija Milanič, Matija Milanič, Boris Majaron, Boris Majaron, } "Analysis of hemodynamics in human skin using photothermal radiometry and diffuse reflectance spectroscopy", Proc. SPIE 10413, Novel Biophotonics Techniques and Applications IV, 104130O (28 July 2017); doi: 10.1117/12.2286043; https://doi.org/10.1117/12.2286043
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