1 August 2017 Real-time three-dimensional temperature mapping in photothermal therapy with optoacoustic tomography
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Ablation and photothermal therapy are widely employed medical protocols where the selective destruction of tissue is a necessity as in cancerous tissue removal or vascular and brain abnormalities. Tissue denaturation takes place when the temperature reaches a threshold value while the time of exposure determines the lesion size. Therefore, the spatio-temporal distribution of temperature plays a crucial role in the outcome of these clinical interventions. We demonstrate fast volumetric temperature mapping with optoacoustic tomography based on real-time optoacoustic readings from the treated region. The performance of the method was investigated in tissue-mimicking phantom experiments. The new ability to non-invasively measure temperature volumetrically in an entire treated region with high spatial and temporal resolutions holds potential for improving safety and efficacy of thermal ablation and to advance the general applicability of laser-based therapy.
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Francisco Javier Oyaga Landa, Francisco Javier Oyaga Landa, Xosé Luís Deán-Ben, Xosé Luís Deán-Ben, Ronald Sroka, Ronald Sroka, Daniel Razansky, Daniel Razansky, } "Real-time three-dimensional temperature mapping in photothermal therapy with optoacoustic tomography", Proc. SPIE 10415, Opto-Acoustic Methods and Applications in Biophotonics III, 104150A (1 August 2017); doi: 10.1117/12.2285568; https://doi.org/10.1117/12.2285568

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