Optical, colloidal and biological properties of up-converting nanoparticles embedded in polyester nanocarriers

Dominika Wawrzyńczyk; Julita Kulbacka; Urszula Bazylińska

doi:10.1117/12.2271694

22 August 2017 Optical, colloidal and biological properties of up-converting nanoparticles embedded in polyester nanocarriers

Dominika Wawrzyńczyk, Julita Kulbacka, Urszula Bazylińska

Author Affiliations +

Proceedings Volume 10453, Third International Conference on Applications of Optics and Photonics; 104530K (2017) https://doi.org/10.1117/12.2271694
Event: Third International Conference on Applications of Optics and Photonics, 2017, Faro, Portugal

Abstract

We have investigated the change in optical properties and biocompatibility of up-converting NaYF4 nanoparticles (NPs) upon encapsulation inside the polyester nanocarriers (NCs) stabilized by Crempophor RH40 (CRH40), poly(D,L-lactide) (PLA), Pluronic P123 (P123). NaYF₄:Er³⁺,Yb³⁺ NPs showed intense green and red emission, and upon encapsulation the increase of red band in respect to green one was observed, with no luminescence lifetime shortening. Obtained NCs showed prolonged colloidal stability and protective effect of the polymer shell simultaneously preserving the high emission efficiency of nanoparticles embedded within the silicon oil (SO) core. Based on emission spectra, kinetic measurements and cytotoxicity studies upon human malignant melanoma Me45 cell line we have shown the advantages of using polyester NCs as containers for the up-converting NPs. Due to the possibility of co-encapsulation of photosensitizers the obtained nanocarriers showed potential for application in theranostics.

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Dominika Wawrzyńczyk, Julita Kulbacka, and Urszula Bazylińska "Optical, colloidal and biological properties of up-converting nanoparticles embedded in polyester nanocarriers", Proc. SPIE 10453, Third International Conference on Applications of Optics and Photonics, 104530K (22 August 2017); https://doi.org/10.1117/12.2271694

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