22 August 2017 Surface enhanced Raman spectroscopy analysis of HeLa cells using a multilayer substrate
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Proceedings Volume 10453, Third International Conference on Applications of Optics and Photonics; 1045312 (2017) https://doi.org/10.1117/12.2272026
Event: Third International Conference on Applications of Optics and Photonics, 2017, Faro, Portugal
Abstract
Single cell analysis can provide important information regarding cell composition, and can be used for biomedical applications. In this work, a SERS active substrate formed by 3 layers of gold nanospheres and a final layer of gold nanocubes was used for the label-free SERS analysis of HeLa cells. Nanocubes were selected due to the high electromagnetic enhancement expected in nanoparticles with sharp corners. Significant improvement in the reproducibility and quality of SERS spectra was found when compared to the spectra obtained using a nanosphere-only substrate and normal Raman spectroscopy.
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I. A. Aguilar-Hernández, I. A. Aguilar-Hernández, J. L. Pichardo-Molina, J. L. Pichardo-Molina, T. Lopez-Luke, T. Lopez-Luke, N. Ornelas-Soto, N. Ornelas-Soto, } "Surface enhanced Raman spectroscopy analysis of HeLa cells using a multilayer substrate", Proc. SPIE 10453, Third International Conference on Applications of Optics and Photonics, 1045312 (22 August 2017); doi: 10.1117/12.2272026; https://doi.org/10.1117/12.2272026
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