The participation of singlet oxygen in a photocitotoxicity of extract from amazon plant to cancer cells

Anna V. Tcibulnikova; Igor A. Degterev; Valery V. Bryukhanov; Matheus Mantuanelli Roberto; F. D. Campos Pereira; M. A. Marin-Morales; Vasily A. Slezhkin; Ilya G. Samusev

doi:10.1117/12.2283317

2 January 2018 The participation of singlet oxygen in a photocitotoxicity of extract from amazon plant to cancer cells

Anna V. Tcibulnikova, Igor A. Degterev , Valery V. Bryukhanov, Matheus Mantuanelli Roberto , F. D. Campos Pereira, M. A. Marin-Morales, Vasily A. Slezhkin, Ilya G. Samusev

Author Affiliations +

Proceedings Volume 10456, Nanophotonics Australasia 2017; 104563E (2018) https://doi.org/10.1117/12.2283317
Event: SPIE Nanophotonics Australasia, 2017, Melbourne, Australia

Abstract

We have been searching for new photosensitizers (PS) for photodynamic therapy (PDT) of cancer based on extracts from Amazonian plants since 2009. In this paper, we demonstrate that, under certain conditions, the extract from fruits of the Amazonian palm Euterpe oleraceae (popular name Açaí) can serve as a PS for PDT treatment of murine breast cancer cells (4T1 cell line). We have been first to show directly that the photodynamic effect of plant PS is due to singlet oxygen.

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Anna V. Tcibulnikova, Igor A. Degterev , Valery V. Bryukhanov, Matheus Mantuanelli Roberto , F. D. Campos Pereira, M. A. Marin-Morales, Vasily A. Slezhkin, and Ilya G. Samusev "The participation of singlet oxygen in a photocitotoxicity of extract from amazon plant to cancer cells", Proc. SPIE 10456, Nanophotonics Australasia 2017, 104563E (2 January 2018); https://doi.org/10.1117/12.2283317

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