Large aspheric surface，which have the deviation with spherical surface，are being used widely in various of optical systems. Compared with spherical surface, Large aspheric surfaces have lots of advantages, such as improving image quality, correcting aberration, expanding field of view, increasing the effective distance and make the optical system compact, lightweight. Especially, with the rapid development of space optics, space sensor resolution is required higher and viewing angle is requred larger. Aspheric surface will become one of the essential components in the optical system. After finishing Aspheric coarse Grinding，surface profile error is about Tens of microns.In order to achieve the final requirement of surface accuracy,the aspheric surface must be quickly modified, high precision testing is the basement of rapid convergence of the surface error . There many methods on aspheric surface detection, Geometric ray detection, hartmann detection, ronchi text, knifeedge method, direct profile test, interferometry, while all of them have their disadvantage. In recent years，the measure of the aspheric surface become one of the import factors which are restricting the aspheric surface processing development. A two meter caliber industrial CMM（coordinate measuring machine） is avaiable, but it has many drawbacks such as large detection error and low repeatability precision in the measurement of aspheric surface coarse grinding , which seriously affects the convergence efficiency during the aspherical mirror processing. To solve those problems, this paper presents an effective error control, calibration and removal method by calibration mirror position of the real-time monitoring and other effective means of error control, calibration and removal by probe correction and the measurement mode selection method to measure the point distribution program development. This method verified by real engineer examples, this method increases the original industrial-grade coordinate system nominal measurement accuracy PV value of 7 microns to 4microns, Which effectively improves the grinding efficiency of aspheric mirrors and verifies the correctness of the method. This paper also investigates the error detection and operation control method, the error calibration of the CMM and the random error calibration of the CMM .