7 February 2018 Optical clearing of vaginal tissues in cadavers
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Abstract
A nonsurgical laser procedure is being developed for treatment of female stress urinary incontinence (SUI). Previous studies in porcine vaginal tissues, ex vivo, as well as computer simulations, showed the feasibility of using near-infrared laser energy delivered through a transvaginal contact cooling probe to thermally remodel endopelvic fascia, while preserving the vaginal wall from thermal damage. This study explores optical properties of vaginal tissue in cadavers as an intermediate step towards future pre-clinical and clinical studies. Optical clearing of tissue using glycerol resulted in a 15-17% increase in optical transmission after 11 min at room temperature (and a calculated 32.5% increase at body temperature). Subsurface thermal lesions were created using power of 4.6 - 6.4 W, 5.2-mm spot, and 30 s irradiation time, resulting in partial preservation of vaginal wall to 0.8 - 1.1 mm depth.
© (2018) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Chun-Hung Chang, Chun-Hung Chang, Luke A. Hardy, Luke A. Hardy, Michael G. Peters, Michael G. Peters, Dina A. Bastawros, Dina A. Bastawros, Erinn M. Myers, Erinn M. Myers, Michael J. Kennelly, Michael J. Kennelly, Nathaniel M. Fried, Nathaniel M. Fried, } "Optical clearing of vaginal tissues in cadavers", Proc. SPIE 10468, Therapeutics and Diagnostics in Urology 2018, 104680K (7 February 2018); doi: 10.1117/12.2285079; https://doi.org/10.1117/12.2285079
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