Quantitative evaluation of retinal degeneration in royal college of surgeons rats by contrast enhanced ultrahigh resolution optical coherence tomography

Jia-Pu Syu; Min-Jyun Su; Po-Wei Chen; Chang-Chih Ke; Shih-Hwa Chiou; Wen-Chuan Kuo

doi:10.1117/12.2289610

19 February 2018 Quantitative evaluation of retinal degeneration in royal college of surgeons rats by contrast enhanced ultrahigh resolution optical coherence tomography

Jia-Pu Syu, Min-Jyun Su, Po-Wei Chen, Chang-Chih Ke, Shih-Hwa Chiou, Wen-Chuan Kuo

Author Affiliations +

Proceedings Volume 10474, Ophthalmic Technologies XXVIII; 104741V (2018) https://doi.org/10.1117/12.2289610
Event: SPIE BiOS, 2018, San Francisco, California, United States

Abstract

This study presents a spectral domain optical coherence tomography (SD-OCT) using supercontinuum laser combined with a fundus photography for in vivo high-resolution imaging of retinal degeneration in Royal College of Surgeons (RCS-/- rat). These findings were compared with the Sprague-Dawley (SD) rats and the corresponding histology. Quantitative measurements show that changes in thickness were not significantly different between SD control and young RCS retinas (4 weeks). However, in old RCS rats (55 weeks), the thickness of photoreceptor layer decreased significantly as compared to young RCS rats (both 4 weeks and 5 weeks). After contrast enhancement method, this platform will be useful for the quantitative evaluation of the degree of retinal degeneration, treatment outcome after therapy, and drug screening development in the future.

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Jia-Pu Syu, Min-Jyun Su, Po-Wei Chen, Chang-Chih Ke, Shih-Hwa Chiou, and Wen-Chuan Kuo "Quantitative evaluation of retinal degeneration in royal college of surgeons rats by contrast enhanced ultrahigh resolution optical coherence tomography", Proc. SPIE 10474, Ophthalmic Technologies XXVIII, 104741V (19 February 2018); https://doi.org/10.1117/12.2289610

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