Fluorescent humanized anti-CEA antibody specifically labels metastatic pancreatic cancer in a patient-derived orthotopic xenograft (PDOX) mouse model

Thinzar M. Lwin; Kentaro Miyake; Takashi Murakami; Jonathan C. DeLong; Paul J. Yazaki; John E. Shivley; Bryan Clary; Robert M. Hoffman; Michael Bouvet

doi:10.1117/12.2292546

1 March 2018 Fluorescent humanized anti-CEA antibody specifically labels metastatic pancreatic cancer in a patient-derived orthotopic xenograft (PDOX) mouse model

Thinzar M. Lwin, Kentaro Miyake, Takashi Murakami, Jonathan C. DeLong, Paul J. Yazaki, John E. Shivley, Bryan Clary, Robert M. Hoffman, Michael Bouvet

Author Affiliations +

Proceedings Volume 10478, Molecular-Guided Surgery: Molecules, Devices, and Applications IV; 104780O (2018) https://doi.org/10.1117/12.2292546
Event: SPIE BiOS, 2018, San Francisco, California, United States

Abstract

Specific tumor targeting can result in selective labeling of cancer in vivo for surgical navigation. In the present study, we show that the use of an anti-CEA antibody conjugated to the near-infrared (NIR) fluorescent dye, IRDye800CW, can selectively target and label pancreatic cancer and its metastases in a clinically relevant patient derived xenograft mouse model.

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Thinzar M. Lwin, Kentaro Miyake, Takashi Murakami, Jonathan C. DeLong, Paul J. Yazaki, John E. Shivley, Bryan Clary, Robert M. Hoffman, and Michael Bouvet "Fluorescent humanized anti-CEA antibody specifically labels metastatic pancreatic cancer in a patient-derived orthotopic xenograft (PDOX) mouse model", Proc. SPIE 10478, Molecular-Guided Surgery: Molecules, Devices, and Applications IV, 104780O (1 March 2018); https://doi.org/10.1117/12.2292546

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