Structural Cherenkov luminescence imaging with Hadamard-patterned field illumination (Conference Presentation)

Mengyu Jia; Petr Bruza; Ethan Philip M. Larochelle; Jennifer R. Shel; Brian W. Pogue

doi:10.1117/12.2292932

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14 March 2018 Structural Cherenkov luminescence imaging with Hadamard-patterned field illumination (Conference Presentation)

Mengyu Jia, Petr Bruza, Ethan Philip M. Larochelle, Jennifer R. Shel, Brian W. Pogue

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Proceedings Volume 10478, Molecular-Guided Surgery: Molecules, Devices, and Applications IV; 1047814 (2018) https://doi.org/10.1117/12.2292932
Event: SPIE BiOS, 2018, San Francisco, California, United States

Abstract

Cherenkov-excited luminescence scanned imaging (CELSI) has been proposed for radiation-dose determination in medical physics due to its high spatial-resolution over centimeters of tissue. However, dense line-scanning illumination in typical CELSI is time-cost owing to the mechanical movement of the leaves in multi leaf collimator (MLC), resulting into increased radiation exposure. As a result, a scanningless Cherenkov luminescence imaging modality is herein proposed through structuring epi-illumination with MLC-based Hadamard-patterns, which utilizes a reduced radiation does by limiting illumination patterns, extremely shortening the sampling process. In order to effectively reconstruct unknowns from the resultant underdetermined linear system with sparse samplings, a compressed sensing-based reconstruction methodology with l1-norm regularization is adopted. Numerical and phantom experiments show that the proposed methodology achieves the same image quality as the traditional CELSI does.

Conference Presentation

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Mengyu Jia, Petr Bruza, Ethan Philip M. Larochelle, Jennifer R. Shel, and Brian W. Pogue "Structural Cherenkov luminescence imaging with Hadamard-patterned field illumination (Conference Presentation)", Proc. SPIE 10478, Molecular-Guided Surgery: Molecules, Devices, and Applications IV, 1047814 (14 March 2018); https://doi.org/10.1117/12.2292932

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