Stroke is an obstinate and dreaded disease, which present characteristics of high incidence rates, high relapse rates, high mortality rates and high disability rates. Recent World Health Organization data suggest that a stroke victim is identified every 6 seconds around the world. There are not effective therapies for stroke except surgery that caused stroke victims enormous physical and psychological trauma. Transcranial low-level light/laser therapy (LLLT) of neurological diseases and brain trauma has gained momentum due to the character of high-efficiency, safe and non-invasive in the past decade. In this study, we found three conclusions through previous studies. 1). In simulation, 810nm light/laser makes the maximum light penetration (>5cm), which allow light to cross through gray matter into white matter. Gaussian beam with the same size of lesion area achieves better therapeutic. What’s more, multi-light/laser- source has potential effect on stroke treatment. 2). In animal tests, LLLT has a positive therapeutic effect and PW mode LLLT has a better effect than XW mode LLLT on stroke treatment. 3). In clinical, large scale human experiment results are not so ideal due to the lower energy density of LLLT. In summary, it is no deny that those research results highlighted the great potential of transcranial LLLT as a novel, effective, and non-invasive therapy for stroke treatment.