12 February 2018 Measurement of shear-induced diffusion of red blood cells using dynamic light scattering-optical coherence tomography
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Proceedings Volume 10481, Neural Imaging and Sensing 2018; 104811N (2018) https://doi.org/10.1117/12.2290345
Event: SPIE BiOS, 2018, San Francisco, California, United States
Abstract
Dynamic Light Scattering-Optical Coherence Tomography (DLS-OCT) takes the advantages of using DLS to measure particle flow and diffusion within an OCT resolution-constrained 3D volume, enabling the simultaneous measurements of absolute RBC velocity and diffusion coefficient with high spatial resolution. In this work, we applied DLS-OCT to measure both RBC velocity and the shear-induced diffusion coefficient within penetrating venules of the somatosensory cortex of anesthetized mice. Blood flow laminar profile measurements indicate a blunted laminar flow profile, and the degree of blunting decreases with increasing vessel diameter. The measured shear-induced diffusion coefficient was proportional to the flow shear rate with a magnitude of ~ 0.1 to 0.5 × 10-6 mm2 . These results provide important experimental support for the recent theoretical explanation for why DCS is dominantly sensitive to RBC diffusive motion.
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Jianbo Tang, Jianbo Tang, Sefik Evren Erdener, Sefik Evren Erdener, Baoqiang Li, Baoqiang Li, Buyin Fu, Buyin Fu, Sava Sakadzic, Sava Sakadzic, Stefan A. Carp, Stefan A. Carp, Jonghwan Lee, Jonghwan Lee, David A. Boas, David A. Boas, } "Measurement of shear-induced diffusion of red blood cells using dynamic light scattering-optical coherence tomography", Proc. SPIE 10481, Neural Imaging and Sensing 2018, 104811N (12 February 2018); doi: 10.1117/12.2290345; https://doi.org/10.1117/12.2290345
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