14 February 2018 A novel fiber-free technique for brain activity imaging in multiple freely behaving mice
Author Affiliations +
Abstract
Brain functions and related psychiatric disorders have been investigated by recording electrophysiological field potential. When recording it, a conventional method requires fiber-based apparatus connected to the brain, which however hampers the simultaneous measurement in multiple animals (e.g. by a tangle of fibers). Here, we propose a fiber-free recording technique in conjunction with a ratiometric bioluminescent voltage indicator. Our method allows investigation of electrophysiological filed potential dynamics in multiple freely behaving animals simultaneously over a long time period. Therefore, this fiber-free technique opens up the way to investigate a new mechanism of brain function that governs social behaviors and animal-to-animal interaction.
© (2018) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Shigenori Inagaki, Shigenori Inagaki, Masakazu Agetsuma, Masakazu Agetsuma, Takeharu Nagai, Takeharu Nagai, } "A novel fiber-free technique for brain activity imaging in multiple freely behaving mice ", Proc. SPIE 10482, Optogenetics and Optical Manipulation 2018, 104820I (14 February 2018); doi: 10.1117/12.2302396; https://doi.org/10.1117/12.2302396
PROCEEDINGS
4 PAGES


SHARE
Back to Top