12 February 2018 Hyperspectral near infrared spectroscopy assessment of the brain during hypoperfusion
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Abstract
Two-thirds of out-of-hospital cardiac arrest patients, who survive to hospital admission, die in the hospital from neurological injuries related to cerebral hypoperfusion. Hyperspectral near infrared spectroscopy (hNIRS) is a noninvasive technique that measures the major chromophores in the brain, such as oxygenated hemoglobin, deoxygenated hemoglobin and cytochrome C oxidase ([CCO]), an intracellular marker of oxygen consumption. We have demonstrated that hNIRS is feasible and can detect changes in cerebral oxygenation and metabolism in patients undergoing transcatheter aortic valve insertion (TAVI) – a procedure that temporarily induces sudden hypotension and hypoperfusion that mimics cardiac arrest. Using multi-distance hNIRS, we found that while measured regional oxygen saturation (rSO2) changes resulted mainly from the extra-cerebral tissues, [CCO] changes during cardiac arrests occurred mainly in the brains of patients. We also applied the hNIRS algorithm based on the “2-layer model” to the data to measure cerebral oxygen saturation and [CCO] in patients during the procedure.
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Thu N. Nguyen, Thu N. Nguyen, Wen Wu, Wen Wu, Ermias Woldemichael, Ermias Woldemichael, Vladislav Toronov, Vladislav Toronov, Steve Lin, Steve Lin, } "Hyperspectral near infrared spectroscopy assessment of the brain during hypoperfusion ", Proc. SPIE 10484, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XVI, 1048419 (12 February 2018); doi: 10.1117/12.2288794; https://doi.org/10.1117/12.2288794
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