19 February 2018 A dynamic system with digital lock-in-photon-counting for pharmacokinetic diffuse fluorescence tomography
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Abstract
Pharmacokinetic diffuse fluorescence tomography (DFT) can describe the metabolic processes of fluorescent agents in biomedical tissue and provide helpful information for tumor differentiation. In this paper, a dynamic DFT system was developed by employing digital lock-in-photon-counting with square wave modulation, which predominates in ultra-high sensitivity and measurement parallelism. In this system, 16 frequency-encoded laser diodes (LDs) driven by self-designed light source system were distributed evenly in the imaging plane and irradiated simultaneously. Meanwhile, 16 detection fibers collected emission light in parallel by the digital lock-in-photon-counting module. The fundamental performances of the proposed system were assessed with phantom experiments in terms of stability, linearity, anti-crosstalk as well as images reconstruction. The results validated the availability of the proposed dynamic DFT system.
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Guoyan Yin, Limin Zhang, Yanqi Zhang, Han Liu, Wenwen Du, Wenjuan Ma, Huijuan Zhao, Feng Gao, "A dynamic system with digital lock-in-photon-counting for pharmacokinetic diffuse fluorescence tomography", Proc. SPIE 10486, Design and Quality for Biomedical Technologies XI, 1048613 (19 February 2018); doi: 10.1117/12.2287821; https://doi.org/10.1117/12.2287821
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