13 February 2018 Blood glucose measurement with multiple quantum cascade lasers using hollow-optical fiber-based ATR spectroscopy
Author Affiliations +
Abstract
For non-invasive blood glucose measurement, a measurement system based on mid-infrared ATR spectroscopy equipped with a combination of a QCL as a light source and a hollow-optical fiber as a beam delivery medium is developed. Firstly the measurement sensitivity of the system is evaluated by using glucose solutions and the result shows a significant correlation between optical absorbance and solution concentration. It is also confirmed that the system has a sensitivity that is enough for blood glucose measurement. Then optical absorption of human lips in the mid-infrared wavelength region is measured using a QCL with a wavenumber of 1080 cm-1 where human tissue exhibits strong absorption of glucose and its metabolites. As a result, the measured absorption follows the change of blood glucose well with a time delay of around 10 minutes and correlation factor between the absorbance and the blood glucose level is 0.42.
Conference Presentation
© (2018) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
K. Yoshioka, K. Yoshioka, S. Kino, S. Kino, Y. Matsuura, Y. Matsuura, } "Blood glucose measurement with multiple quantum cascade lasers using hollow-optical fiber-based ATR spectroscopy", Proc. SPIE 10488, Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications XVIII, 104880D (13 February 2018); doi: 10.1117/12.2288131; https://doi.org/10.1117/12.2288131
PROCEEDINGS
6 PAGES + PRESENTATION

SHARE
Back to Top