13 February 2018 Integrated sensor biopsy device for real time tissue metabolism analysis
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Abstract
Current methods for guiding cancer biopsies rely almost exclusively on images derived from X-ray, ultrasound, or magnetic resonance, which essentially characterize suspected lesions based only on tissue density. This paper presents a sensor integrated biopsy device for in situ tissue analysis that will enable biopsy teams to measure local tissue chemistry in real time during biopsy procedures, adding a valuable new set of parameters to augment and extend conventional image guidance. A first demonstrator integrating three chemical and biochemical sensors was tested in a mice strain that is a spontaneous breast cancer model. In all cases, the multisensory probe was able to discriminate between healthy tissue, the edge of the tumor, and total insertion inside the cancer tissue, recording real-time information about tissue metabolism.
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Jesus Delgado Alonso , Jesus Delgado Alonso , Robert A. Lieberman, Robert A. Lieberman, Paul M. DiCarmine, Paul M. DiCarmine, David Berry, David Berry, Narciso Guzman, Narciso Guzman, Sreekar B. Marpu, Sreekar B. Marpu, } "Integrated sensor biopsy device for real time tissue metabolism analysis", Proc. SPIE 10488, Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications XVIII, 104880P (13 February 2018); doi: 10.1117/12.2290323; https://doi.org/10.1117/12.2290323
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