14 February 2018 Fabrication and analysis of cylindrical diffusing optical fiber probe for photodynamic therapy in cancer treatment
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Abstract
The treatment using photodynamic therapy (PDT) among cancer treatment methods shows remedial value in various cancers. The optical fiber probe infiltrates into affected parts of the tissues that are difficult to access, such as pancreatic cancer, carcinoma of extrahepatic bile duct, prostate cancer, and bladder cancer by using endoscopic retrograde cholangiopancreatography (ERCP) and endoscopic ultrasonography (EUS) with various types of diffusing tips.

In this study, we developed cylindrical diffusing optical fiber probe (CDOFP) for PDT, manufactured ball-shaped end which is easily infiltrated into tissues with diffusing length ranging from 10mm to 40mm through precision laser processing, and conducted beam profile characterization of manufactured CDOFP. Also, chemical reaction between photo-sensitizer and laser in PDT is important, and hence the thermal effect in tissues as per diffusing length of probe was also studied as it was used in a recent study.
Conference Presentation
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Gaye Park, HyeYeon Lee, HyungSu Cho, DaeYoung Kim, JaeWan Han, ChiHwan Ouh, ChangHyun Jung, "Fabrication and analysis of cylindrical diffusing optical fiber probe for photodynamic therapy in cancer treatment", Proc. SPIE 10488, Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications XVIII, 1048811 (14 February 2018); doi: 10.1117/12.2289343; https://doi.org/10.1117/12.2289343
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