19 February 2018 Mid-infrared fiber-coupled supercontinuum spectroscopic imaging using a tapered chalcogenide photonic crystal fiber
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Abstract
We present the first demonstration of mid-infrared spectroscopic imaging of human tissue using a fiber-coupled supercontinuum source spanning from 2-7.5 μm. The supercontinuum was generated in a tapered large mode area chalcogenide photonic crystal fiber in order to obtain broad bandwidth, high average power, and single-mode output for good imaging properties. Tissue imaging was demonstrated in transmission by raster scanning over a sub-mm region of paraffinized colon tissue on CaF2 substrate, and the signal was measured using a fiber-coupled grating spectrometer. This demonstration has shown that we can distinguish between epithelial and surrounding connective tissues within a paraffinized section of colon tissue by imaging at discrete wavelengths related to distinct chemical absorption features.
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Christian Rosenberg Petersen, Christian Rosenberg Petersen, Nikola Prtljaga, Nikola Prtljaga, Mark Farries, Mark Farries, Jon Ward, Jon Ward, Bruce Napier, Bruce Napier, Gavin Rhys Lloyd, Gavin Rhys Lloyd, Jayakrupakar Nallala, Jayakrupakar Nallala, Nick Stone, Nick Stone, Ole Bang, Ole Bang, } "Mid-infrared fiber-coupled supercontinuum spectroscopic imaging using a tapered chalcogenide photonic crystal fiber", Proc. SPIE 10489, Optical Biopsy XVI: Toward Real-Time Spectroscopic Imaging and Diagnosis, 1048905 (19 February 2018); doi: 10.1117/12.2288541; https://doi.org/10.1117/12.2288541
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