13 February 2018 Robust and brilliant Raman tags based on core-satellite assemblies for brain tumor cell imaging
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Abstract
GBM (Glioblastoma Multiforme), a fatal brain tumor, is highly infiltrative and difficult to be completely removed by the surgery. In this work, the Raman tags based on the plasmonic core-satellite assemblies with ~1 nm internal gap accompanied by extremely high gap field have been fabricated and applied to GBM cell labeling. The brightness of the Raman tags is comparable to the fluorophores. The GBM cells with overexpression of EGFR are labeled with these Raman tags and can be distinguished from the normal cells through Raman imaging.
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Yung-Ching Chang, Yung-Ching Chang, Li-Ching Huang, Li-Ching Huang, Wei-Lun Sun, Wei-Lun Sun, Shih Yi Chuang, Shih Yi Chuang, Tien-Hsin Lin, Tien-Hsin Lin, Yi-Syuan Wu, Yi-Syuan Wu, Chun-I Sze, Chun-I Sze, Shiuan-Yeh Chen, Shiuan-Yeh Chen, } "Robust and brilliant Raman tags based on core-satellite assemblies for brain tumor cell imaging", Proc. SPIE 10490, Biomedical Vibrational Spectroscopy 2018: Advances in Research and Industry, 1049006 (13 February 2018); doi: 10.1117/12.2290194; https://doi.org/10.1117/12.2290194
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