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13 February 2018 Optical coherence tomography angiography and cutaneous wound healing
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Background: Examination of the skin’s vascular and structural features is essential in clinical, medical, and research dermatology. However, there is a lack of comprehensive imaging tools that clearly and accurately evaluates the skin’s vascular and structural features. Current techniques are invasive and have inherent preparatory drawbacks. Aim: To use optical coherence tomography angiography (OCTA) for a more accurate depiction of vessels in the skin without the use of a dye or other invasive techniques to visualize and asses the role of the skin’s vasculature during the process’ of wound healing. Method: We used an in-house-built, swept source-OCT system to perform OCTA analyses so as to image the vascular features of a cutaneous wound to a depth of 1.2 mm as it was healing. Key vascular parameters, such as vessel density and diameter, were measured at various depths to elucidate how depth might influence the vascular response. Observation: We found that alterations to the vasculature of the skin are linked to active healing. The first response of the superficial vessels observed here is to increase in diameter, whilst the first response of the deeper vessels is to increase in density. Additionally, the superficial vessels appear to normalize at an earlier compared to deeper vessels. Conclusion: OCTA is capable of imaging and distinguishing the complex collection of events that play pivotal roles in the repair of healthy skin that could be useful in the assessment of skin repair and treatment after injury or surgery.
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Wendy Wang, Anthony J. Deegan, Shaojie Men, and Ruikang K. Wang "Optical coherence tomography angiography and cutaneous wound healing", Proc. SPIE 10493, Dynamics and Fluctuations in Biomedical Photonics XV, 104930D (13 February 2018);

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